Research
Chronic low back pain (LBP) is the leading cause of disability worldwide, and carries a tremendous economic burden.
A ground-breaking new study led by researchers from the Lady Davis Institute (LDI) at the Jewish General Hospital (JGH) has succeeded in compiling an atlas of genetic factors associated with estimated bone mineral density (BMD), one of the most clinically relevant factors in diagnosing osteoporosis. The paper, published in Nature Genetics, identifies 518 genome-wide loci, of which 301 are newly discovered, that explain 20% of the genetic variance associated with osteoporosis. Having identified so many genetic factors offers great promise for the development of novel targeted therapeutics to treat the disease and reduce the risk of fracture.
An estimated 50 million adults in the United States were living with chronic noncancer pain in 2016 and many of them were prescribed opioid medications, even though a clinical benefit is uncertain.
A minimally invasive procedure in which pulses of energy from a probe are applied directly to nerve roots near the spine is safe and effective in people with acute lower back pain that has not responded to conservative treatment, according to a study being presented today at the annual meeting of the Radiological Society of North America (RSNA).
An intervention combining passive joint mobilization to realign the patellar (kneecap) position, along with exercise to maintain it, can reduce pain and improve function and quality in life in patients with knee osteoarthritis.
A higher polygenic risk score—a genetic analysis computed from a combination of several of a person’s genes—is associated with more frequent and severe headaches, according to the results of a new study from researchers at New York-Presbyterian/Weill Cornell Medical Center in New York, NY and the University of Michigan in Ann Arbor, MI. The findings support the idea that a propensity for headaches has a genetic basis.
Risk factors of Type 2 diabetes and cardiovascular disease accumulate in children who have poor aerobic fitness, a new study from the University of Eastern Finland shows.
Three paraplegics who sustained cervical spinal cord injuries many years ago are now able to walk with the aid of crutches or a walker thanks to new rehabilitation protocols that combine targeted electrical stimulation of the lumbar spinal cord and weight-assisted therapy.
The objective of this systematic review and meta-analysis was to quantify the magnitude of effect of neural tissue management (NTM) on pain and disability in patients with chronic musculoskeletal pain.
A new study in the journal Rheumatology indicates that being exposed to secondhand smoke in childhood could increase the risk of someone developing arthritis as an adult.
Cervical radiculopathy describes radiating pain into the arm corresponding to a dermatomal pattern. Radiculopathy is, by definition, a neurological state characterized by limited or blocked nerve conduction and differentiated from radicular pain, wherein the compression can be caused by the cervical disc, degenerative changes or simple inflammation.
Some people respond well to both aerobic exercise and strength training, while others don't. And some of us respond well to only one of those things, but not both. Scientists at Joslin Diabetes Center now have uncovered a surprising molecular "switch" that may help to explain this lack of response to exercise and to give clues to better treatments against diabetes.
Could increasing your physical activity or feeling more in control of your life be the secret to staying young? Employing these simple strategies may help older adults feel younger and that, in turn, could help improve their cognitive abilities, longevity and overall quality of life, according to research presented at the annual convention of the American Psychological Association.
Among convicted offenders, receiving methadone is associated with lower rates of death from external and non-external causes, according to new research published this week in PLOS Medicine by Angela Russolillo of Simon Fraser University, Canada, and colleagues.
Faced with the epidemic of opioid addiction, researchers have been charged with finding other strategies to treat pain. Their efforts largely have focused on nerve cells that transmit pain signals to the spinal cord and brain. But new research, led by scientists at Washington University School of Medicine in St. Louis, shows that targeting receptors on immune cells may be more effective, particularly for chronic pain.
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