Opioids vs. placebo, nonopioid alternatives for chronic noncancer pain
An estimated 50 million adults in the United States were living with chronic noncancer pain in 2016 and many of them were prescribed opioid medications, even though a clinical benefit is uncertain.
This study combined the results of 96 randomized clinical trials with about 26,000 participants to compare opioids with placebo and nonopioid alternative pain medications for the treatment of chronic noncancer pain. Opioids were associated with small improvements in pain and physical functioning plus increased risk of vomiting compared with placebo. Comparisons of opioids with nonopioid pain medication alternatives suggest the benefit for pain and functioning may be similar but the quality of evidence from the studies wasn't high. None of the studies provided rates of developing opioid use disorder.
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